Dr. Gal Goldstein

EDUCATION AND RESIDENCE

• 1998 – B.Sc in life sciences, Tel Aviv University, Israel
• 1999 – M.D. Sackler School of medicine, Tel Aviv University, Israel
• 1999 – 2002 – Pediatric medicine, Assaf Harofe medical center Israel

FELLOWSHIP

• 2003-2006 – Pediatric Hemato-Oncology, The Edmond and Lily Safra children’s hospital, Tel Hashomer, Israel

POST FELLOWSHIP TRAINING

• 2006 June-July – Haploidentical Bone Marrow Transplantation, under the supervision of Prof. Rupert Handgretinger, Tuebingen, Germany

AWARDS AND PRIZES    

• 2009 – Best oral presentation- in ‘Israeli Society of Pediatric Hemato Oncology annual meeting’ – Ein Gev
• 2010 – Employee Award of Excellence – Sheba medical center

FIELDS OF INTEREST

• Bone marrow transplantations in children
• Haploidentical bone marrow transplantations
• Cord blood transplantations in children
• Chronic Graft Versus Host Disease in children Initiator and head of CGVHD clinic

BASIC SCIENCE RESEARCH

• 1990 – Apo-E protein expression in Alzheimer disease rat model. Neurobiology laboratory, TelAviv University
• 2009 – Erythropeitin expression in cells with VHL mutation C548T, Hematology laboratory, Tel Hashomer

PUBLICATIONS

Chapter in a book:

• Gal Goldstein, Amos Toren, Arnon Nagler, Human Umbilical Cord Blood Transplantation: A viable option for stem cell graft. in Stem Cell and Gene-Based Therapy: in Frontiers Regenerative Medicine. Springer-Verlag (London) Ltd. 2005

Original articles

First author:

• Goldstein G, Shpilberg O, Raanani P, Chetrit A, Ben-Bassat I.
  Treatment of adults with acute lymphoblastic leukemia-results at the Sheba Medical Center, Tel-Hashomer, 1977-1988 Harefuah. 2000;139:255-9
• Goldstein G, Elhasid R, Bielorai B, Shimoni A, Yerushalmi R, Kassis I, Nagler A. Adults requiring cord blood transplants but have insufficient cell doses from a single cord blood unit can receive two units with successful engraftment kinetics similar to those of children receiving a single unit.Leukemia&Lymphoma.2011;52:635-41
• Goldstein G, Bielorai B, Stein J, Stepensky P, Elhasid R,Chetrit A,Yaniv I, Nagler A, Toren A. Analysis of risk factors of cord blood transplantation for children. Pediatric Blood and Cancer, 2013;60:2007-11
• Goldstein G, Maor J ,Kleinbaum Y, Palumbo M, Sidi Y,Salomon O. Budd- Chiari Syndrome in Very Young Adult Patients with Polycythem​ia Vera -Report of Case Series with Good Outcome with Direct Thrombin Inhibitor Treatment. Blood Coagulation and Fibrinolysis, 2013;24:848-53
• Goldstein G, Bielorai B, Keller N, Bilik R, Toren A. Do immunocompromised children benefit from having surgical lung biopsy performed? ACTA Haematologica  .2015;133(2):205-9
• Goldstein G, Shemesh E, Frenkel T, Jacobson JM, Toren A. Abnormal body mass index at diagnosis of patients with Ewing sarcoma is associated with inferior tumor Pediatr Blood Cancer. 2015 Nov;62(11):1892-6
• Goldstein G., Rutenberg TF, Mendelovich SL, Hutt D, Oikawa MT, Toren A, Bielorai B. The role of immunoglobulin prophylaxis for prevention of cytomegalovirus infection in pediatric hematopoietic stem cell transplantation recipients. Pediatr Blood Cancer 2017; 2017 Jul;64(7).

Original articles:

• Efrati O, Toren A, Duskin H, Modan-Moses D, Bielorai B, Goldstein G, Churi C, Vilozni D. Pulmonary function studies in children treated by chemoradiotherapy and stem cell transplantation. Pediatr Blood Cancer. 2008 ;51:684-8
• Simchen MJ, Goldstein G, Lubetsky A, Strauss T, Schiff E, Kenet G Factor V Leiden and Antiphospholipid Antibodies in Either Mothers or Infants Increase the Risk for Perinatal Arterial Ischemic Stroke. Stroke. 2009 ;40:65-70
• Efrati O, Toren A, Duskin H, Goldstein G, Jacobson JM, Churi C, Vilozni D Spirometry follow-up in young children with hemato-oncologic diseases. Med Sci Monit. 2010 ;16: 28-33
• Waldman D, Manashku S, Strauss T, Goldstein G, Ben-Zeev B, Kenet G [Thrombophilia and thrombosis in children–lessons from cerebral sinus vein thrombosis registry of a tertiary center].[Article in Hebrew] Harefuah.2010 ;149:270-3, 337.
• Revel-Vilk S, Yacobovich J, Tamary H, Goldstein G, Nemet S, Weintraub M, Paltiel O, Kenet G. Risk factors for central venous catheter thrombotic complications in children and adolescents with cancer. 2010 1;116:4197-205.
• Givol N, Goldstein G, Peleg O, Shenkman B, Zimran A, Elstien D, Kenet G. Thrombocytopenia and bleeding in Dental procedures of patients with Gaucher disease. Haemophila, 2012 ;18:117-2
• Weyl Ben-Arush M, Ben Barak A, Bar-Deroma R, Ash S, Goldstein G, Golan H, Houri H, Waldman D, Nevo N, Bar Shalom R, Berniger A, Nevelsky A, Toren A, Yaniv I, Kuten A. Targeted therapy with low doses of 131I-MIBG is effective for disease palliation in highly refractory neuroblastoma.. Isr Med Assoc J. 2013 ;15:31-4.
• Stepensky P1, Krauss A, Goldstein G, Zaidman I, Elhasid R, Bielorai B, Somech R, Or R, Stein J , Revel-Vilk S, Weintraub M. Impact of conditioning on outcome of hematopoietic stem cell transplantation for wiskott-Aldrich syndrome. J Pediatr Hematol Oncol. 2013 ;35
• Yacobovich J1, Ben-Ami T, Abdalla T, Tamary H, Goldstein G, Weintraub M, Yaniv I, Toren A, Kenet G, Revel-Vilk S. Patient and central venous catheter related risk factors for blood stream infections in children receiving chemotherapy. Pediatr Blood Cancer. 2015;62:471-6.
• Tsirigotis P, Danylesko I, Gkirkas K, Shem-Tov N, Yerushalmi R, Stamouli M, Avigdor A, Spyridonidis A, Gauthier J, Goldstein G, Apostolidis J, Mohty M, Shimoni A, Nagler A. Brentuximab vedotin in combination with or without donor lymphocyte infusion for patients with Hodgkin lymphoma after allogeneic stem cell transplantation. Bone Marrow Transplant. 2016 May 16. [Epub ahead of print]
• Bielorai B, Weintraub Y, Hutt D, Hemi R, Kanety H, Modan-Moses D, Goldstein G, Hadar D, Lerner-Geva L, Toren A, Pinhas-Hamiel O. The metabolic syndrome and its components in pediatric survivors of allogeneic hematopoietic stem cell transplantation. Clin Transplant. 2017 Mar;31(3). doi: 10.1111/ctr.12903.
• Jacoby E, Varda-Bloom N, Goldstein G, Hutt D, Churi C, Vernitsky H, Toren A, Bielorai B. Comparison of two cytoreductive regimens for αβ-T-cell-depleted haploidentical HSCT in pediatric malignancies: Improved engraftment and outcome with TBI-based regimen. Pediatr Blood Cancer. 2018 Feb;65. Epub 2017 Oct 8.
• Shreberk-Hassidim R¹, Neumark M, Greenberger S, Goldstein G, Hassidim A, Dukler Y, Maly A, Stepensky P, Molho-Pessach V. Cutaneous Chronic Graft Versus Host Disease Following Allogeneic Haematopoietic Stem Cell Transplantation in Children: A Retrospective Study.Acta Derm Venereol. 2018 Feb 7;98(2):206-211. doi: 10.2340/00015555-2824

• Bielorai B, Leitner M, Goldstein G, Mehrian-Shai R, Trakhtenbrot L, Fisher T, Marcu V, Yalon M, Schiby G, Barel O, Cal N, Golan H, Toren A. Sustained Response to Imatinib in a Pediatric Patient with Concurrent Myeloproliferative Disease and Lymphoblastic Lymphoma Associated with a CCDC88C-PDGFRB Fusion Gene. Acta Haematol. 2019 Feb 6;141(2):119-127.
• Picarsic J, Pysher T, Zhou H, Fluchel M, Pettit T, Whitehead M, Surrey LF, Harding B, Goldstein G, Fellig Y, Weintraub M, Mobley BC, Sharples PM, Sulis ML, Diamond EL, Jaffe R, Shekdar K, Santi M. BRAF V600E mutation in Juvenile Xanthogranuloma family neoplasms of the central nervous system (CNS-JXG): a revised diagnostic algorithm to include pediatric Erdheim-Chester disease. Acta Neuropathol Commun. 2019 Nov 4;7(1):168. doi: 10.1186/s40478-019-0811-

Submitted manuscripts:

• Blincoe A, Heeg M, Campbell P, Hines M, Khojah A, Klein-Gitelman M,  Talano JA, Speckmann C, Touzot F, Lankester A, Legger GE, Rivière JG,  Garcia-Prat M, Alonso L, Putti MC, Lehmberg K, Maier S, El Chazli Y, Abd Elmaksoud MS Astigarraga I, Kurjane N, Bulina I, Kenina V, Bryceson Y,  Rascon J, Lortie A, Goldstein G, Booth C, Worth A, Wassmere E, Schmitt EG, Warren JT, Bednarski JJ, Ali S, Chiang KY, Krueger J, Henry MM, Holland SM, Marsh R, MD, Ehl S, MD, Haddad E. Isolated central nervous system disease in Familial Hemophagocytic Lymphohistiocytosis– a multicenter case series Submitted to JACI in practice.

Accepted manuscripts, in production:

• Barg A, Toren A, Yacobovich J, Steinberg-Shemer J, Gilad O, Goldstein G, Miskin H, Revel-Vilk S, Rosenbeg N, Kenet K, Shkalim Zemer V. Essential thrombocythemia ─ A retrospective case series. Pediatric Blood and Cancer

Case report:

• Goldstein G, Tauber T. Reflex sympathetic dystrophy after routine venipuncture. Isr Med Assoc J. 2004 Oct;6(10):637-8

Reviews:

• Goldstein G, Levi Y, Shoenfeld Y.The X-ANCA antibodies–importance and clinical significance. Harefuah. 1999 15;136:280-2.
• Goldstein G, Toren A, Nagler A. Human umbilical cord blood: Biology, Transplantation and Plasticity. Curr. Med. Chem. 2006;13:1249-59
• Goldstein G., Toren A., Nagler A. Transplantation and other uses of human umbilical cord blood. Curr. Med. Pharm. 2007;13:1363-1373
• Stanevsky A, Goldstein G, Nagler A. Umbilical cord blood transplantation: pros, cons and beyond. Blood Rev.2009 ;23:199-204.

Abstracts :

• Goldstein G, Bielorai B, Nagler A, Hutt D, Neuman Y, Churi H, Toren A.Cord blood transplantation in children – a single institute experience. Bone Marrow Transplant.2005, 35, Suppl 2, S366.
• Goldstein G, Toren A, Bielorai B, Hutt D, Waldman D, Kaplinski C, Modan D. Endocrinopathies in paediatric stem cell transplantation survivals-a single institue experience. Bone Marrow Transplant. 2005, 35, Suppl 2, S354

Posters:

• Goldstein G, El-Hasid R, Bielorai B, TorenA,Yerushalmi R., Shimoni A, Nagler; Similar engraftment kinetics of double units, versus single units in children. Bone Marrow Transplant.2009, 43, Suppl 1, S109.
• Goldstein G, Bielorai B, Stein J, Stepensky P, Elhasid R, Nagler A, Yaniv I, Toren A. The influence of Rh incompatibility on acute graft versus host disease and overall survival in cord blood transplantations in children. Bone Marrow Transplant. 2011