Prof. Simcha Yagel

EDUCATION

• 1969-1977: Hebrew University – Hadassah Medical School, Jerusalem, Israel
• 1977: MD Thesis:Effect of MER treatment of hydrolytic enzyme levels of murine peritoneal macrophages.  Professors R Gallily and D. Weiss, Instructors.
• 1977 1980: Military Service (Physician)
• 1980-1986: Resident in Obstetrics and Gynecology, Hadassah University Hospital, Mt. Scopus, Jerusalem, Israel; Instructor in Obstetrics and Gynecology, Hebrew University – Hadassah Medical School.
• 1985-1986: One year of laboratory research at theLautenberg Center for General and Tumor Immunology, Hebrew University – Hadassah Medical School, Jerusalem, Israel, as part of residency program.
• 1986: Lecturer in Obstetrics and Gynecology,Hadassah University Hospital.
• 1987-1988: Post – doctoral fellowship (MRC Scholar).  P.K. Lala, M.D. PhD, Professor and Chair, Department of Anatomy, Supervisor.
• 1987-1988: Departments of Anatomy and Cancer Research, Dr. D.T. Denhart, Chair, University of Western Ontario, London, Ontario, Canada.
• 1988: The Division of Cancer and Cell Biology, headed by Dr. R.S. Kerbel; Mt. Sinai Research Institute; headed by Dr. L. Simonovitch; and the University of Toronto, Toronto, Ontario,Canada.
• 1989: Senior physician in Obstetrics and Gynecology,Hadassah University Hospital, Mt. Scopus,Jerusalem, Israel.
• 1989: Senior lecturer in Obstetrics and Gynecology, Faculty of Medicine of the Hebrew University – Hadassah Medical School, Jerusalem, Israel.
• 1990: Founder and vice-chairman of the Israel Society of Ultrasound in Obstetrics and Gynecology.
• 1992: Head of the Ultrasound Unit, Department of Obstetrics and Gynecology, Hadassah University Hospital, Mt. Scopus, Jerusalem, Israel.
• 1992-1993: Sabbatical, Laboratory of Radiobiology,University of California, San Francisco, with Profs. Zena Werb and Susan Fisher.
• 1994: Professor of Obstetrics and Gynecology, Faculty of Medicine of the Hebrew University -Hadassah Medical School, Jerusalem, Israel.
• 1999: Member of Morphological Sciences Table of the Department of Anatomy and Cell Biology of the Hebrew University – Hadassah Medical School,Jerusalem, Israel.
• 1999-2002: Chairman of the Israel Society of Ultrasound in Obstetrics and Gynecology.
• 1999: Member of the Scientific Board of Biomedicom Creative Biomedical Computing, Ltd.,Jerusalem, Israel.
• 2000: Editor of Imaging Column in Israel Medical Association Journal, IMAJ.
• 2000: Full Professor of Obstetrics and Gynecology, Faculty of Medicine of the Hebrew University -Hadassah Medical School, Jerusalem, Israel.
• 2001: Member of the Editorial Board, Journal of Ultrasound in Medicine.
• 2002: Member of the Editorial Board, Journal of Ultrasound in Obstetrics and Gynecology.
• 2004: Member of the Board, International Society of Ultrasound in Obstetrics and Gynecology.
• 2005: Member of the Scientific Advisory Board of Insightec Israel.
• 2006: Director of Ultrasound Center, Hadassah-Hebrew University Medical Centers, Department of Obstetrics and Gynecology, Mt.Scopus.
• 2006: Director of Center for Human Placenta Research, Department of Obstetrics and Gynecology, Hadassah-Hebrew University Medical Centers, Mt. Scopus.
• 2008: Member of the Advisory Board of Women’s Health Issues in Thrombosis and Haemostasis
• 2008: Member of the Editorial Board of the JournalPlacenta.
• 2009: Founding member and first Chairman of the Israel Society for Placenta Research.
• 2012: Head Division of Obstetrics and Gynecology,Hadassah Medical Centers, Jerusalem, Israel.

GRANTS AND AWARDS

1. The involvement of interluekines in hCG production by trophoblasts. Pharmacia, 1988-89.
2. Medical Research Council Grant of Canada, 1986-88.
3. Award for excellent abstract, 43^rdAnnual Meeting of the SOGC, 1988, Vancouver, British Columbia, Canada.
4. Award for excellent presentation, 11^thAnnual Trophoblast Research Meeting, 1988, Rochester, NY, USA.
5. Grant from The Joint Fund of the Hebrew University and Hadassah, $5,000, 1990: The effect of extracellular matrix on the activation, secretion, and mRNA expression of collagenase and TIMP by rat granulosa cells.
6. Special grant from the Lautenberg Center for Immunology, $30,000, 1990-91.
7. Special grant by the Hadassah Medical Organization, $15,000, 1990: In-vitro fertilization – Molecular mechanisms involved in blastocyst implantation.
8. Grant of the Israel Ministry of Health, 25,000/year, 1992-3: In-vitro fertilization – Molecular mechanisms in the implantation process.
9. Grant of the United States – Israel Binational Science Foundation, 1994, for 3 years, $36,500 for the first year: Transcriptional regulation of HLA-G expression by cytotrophoblasts and preeclampsia.
10. Grant of the Chief Scientist’s Office, Israel Ministry of Health, 1998, 60,000 NIS/year: The role of invasive trophoblasts and endometrial cells on the regulation of plasminogen activator and metalloproteinases.
11. Grant of the Office of the Administrator General of Israel, 1998, 60,000 NIS/year: The role of invasive trophoblasts and endometrial cells on the regulation of plasminogen activator and metalloproteinases.
12. Award of the Israel Minister of Health for Outstanding Research, 1998: The role of invasive trophoblasts and endometrial cells on the regulation of plasminogen activator and metalloproteinases.
13. Grant of the Israel-U.S. Binational Industrial Research and Development Foundation, 1998: “Fetal Weight Measurement Using 3-D Ultrasound”; $1,600,000, over two years, withBiomedicom, Israel, and ATL, Seattle,Washington, USA.
14. Hadasit – Applied research award – “The use of antisense HLA-G nucleotides as a women’s centered anti-implantation contraceptive”- $36,000/year.
15. PI with Prof. Gomori, MR Guided focused ultrasound surgery in the treatment of uterine fibroids, $130,000 “Insightec”.
16. (Advisor) PI: Dr. Ronit Haimov-Kochman, Dr. Zahava Rengini, The involvement of heparanase in the invasive process of trophoblast cells in human placentas of normal and toxemic pregnancies. Women’s Health Grant, 2000,10,000.
17. PI: Prof. Simcha Yagelwith Dr. Ofer Mandelboim, The role of CD66a (CEACAM 1)-mediated inhibition of activated decidual lymphocytes in normal pregnancy and in maternal CMV and other bacterial and viral infections. Women’s Health Grant, 120,000NIS. 2002, renewed in 2003, 75,000 NIS.
18. (Advisor) PI: Professor Aryeh Hurwitz, Professor Joseph Orly, Expression and significance of sprouty proteins in human granulosa luteinized cells extracted from follicular fluid aspiration in in-vitro fertilization (IVF). Women’s Health Grant, 2002. 87,000NIS.
19. (Advisor) PI: Professor Aryeh Hurwitz, Professor Joseph Orly, Expression and significance of sprouty proteins in human granulosa luteinized cells extracted from follicular fluid aspiration in in-vitro fertilization (IVF). Office of the Chief Scientist, Ministry of Health, 2002, 80,000 NIS.
20. (Advisor) PI: Dr. Ronit Haimov-Kochman and Professor Reuven Reich, The role of heparanase in morphogenesis, angiogenesis and sprouting of mouse and human villous placentae. Women’s Health Grant, 2002, 100,000 NIS.
21. (Advisor) PI: Dr. Ronit Haimov-Kochman and Professor Reuven Reich, The role of heparanase in morphogenesis, angiogenesis and sprouting of mouse and human villous placentae. Chief Scientist and The Public Committee for the Designation of Estate Funds, 2002, 80,000 NIS.
22. PI’s Prof. Simcha Yageland Dr. Ofer Mandelboim, Possible role of NK cells in trophoblast attraction to the decidua. Grant of the Chief Scientist of the Israel Ministry of Health, 2004-2006, 80,000 NIS.
23. (Advisor), PI: Dr. Dan Valsky, Regulation of sFlt-1 in normal placenta and placenta of preeclampsia. Joint Research Fund of the Hebrew Univesity and Hadassah, 2006-2008, $10,000 annually.
24. (Advisor), PI: Dr. Dan Valsky, Regulation of sFlt-1 in normal placenta and placenta of preeclampsia. Women’s Health Grant, 2006-2008, $20,000.
25. Co-Investigator with Dr. Nahum Shpigel, Implantation of immune system and human intestinal explants in mice for the development of a unique model of Crohn’s disease. Bikura Individual Program of the Israel Science Foundation, 2006-2009, 225,000 NIS annually for three years.
26. (Advisor) PI: Dr. Hen Sela. The Expression of Chemokine Receptors in Human Trophectoderm Cells Derived from PGD Embryos and Their Role in ImplantationHadassah-Hebrew University Medical Center – Basic Science Research Fund, 2007, $5,000.
27. (Advisor) PI: Dr. Hen Sela. Human trophectoderm cells derived from PGD embryos, ability to express chemokine receptors role and function in implantationHadassah-Hebrew University Medical Center – Womens Health Research Fund, 2008, $20,000.
28. (Advisor) PI: Dr. Hen Sela. Human trophectoderm cells derived from PGD embryos, ability to express chemokine receptors role and function in implantation. Joint Research Fund of the Hebrew Universityand Hadassah-Hebrew University MedicalCenter, 2008. $11,000.
29. Co-Investigator with PI: Dr. Ronit Kochman, Regulation of blastocyst implantation by maternal endometrial NK cells. Women’s Health Fund, 2008, $20,000.
30. (Advisor) PI: Dr. Hen Sela. Human trophectoderm cells derived from PGD embryos, ability to express chemokine receptors role and function in implantation. Ministry of Health, Office of the Chief Scientist, 2009-2010. $50,000 for 2 consecutive years.
31. Co-Investigator with PI: Dr. Ronit Kochman, Prenatal determinants of congenital human cytomegalovirus disease: correlation of ex-vivo modeling with maternal and fetal clinical samples. Women’s Health Fund, 2009, $20,000.
32. (Collaborator) PI: Prof. Dana Wolf, Dr. Amos Panet. Prenatal Determinants of Congenital Human Cytomegalovirus Disease: Correlation of ex vivo Modeling with Prenatal Clinical Samples. Israel Science Foundation, 2009-2013, 195,000 NIS annually for 4 years.
33. Co-PI Prof. Simcha Yagel with Dr. Yaron Hamani. A functional and temporal analysis of human decidual NK cells and their role in pregnancy. Hadassah Internal Grant Fund, 60,000 NIS, 2010.
34. PI Prof. Simcha Yagel. A functional and temporal analysis of the NK cells in the reproductive system. Compensatory Fund, 50,000 NIS, 2010.
35. Co-Investigator with Dr. Ronit Kochmnan. Regulation of blastocyst implantation by maternal endometrial NK cells. Office of the Chief Scientist, Ministry of Health, 200,000 NIS/year for two years, 2010-2012.